Natalie Minks know that strange things happen at crossroads, but the crossroads at Arcane, Missouri seem awful boring, until Dr. Jake Limberleg and his medicine show come to Arcane and turn everything upside down. When her mother becomes ill, whispers engulf the town in uncertainty and Limberleg prescribes odd medicines, Natalie knows something is up. She uncovers "bone shaking" secrets and finds that the town's future rests in her hands.